It can develop in isolation (primary RLS) or as a consequence of another disorder (secondary RLS). Other conditions that can produce RLS include renal disease, diabetes, pregnancy, iron-deficiency, polyneuropathy, and as a side-effect of certain medications.
Other disorders can produce a similar type of calf pain and should be considered. Some of these conditions include neurogenic claudication, vascular claudication, polyneuropathy, and akathesia.
This disorder often responds to dopamine agonists although some anticonvulsants, opioid agents, and muscle relaxants can provide relief as well.
For more information … www.RLS.org